Research Associate/Senior Research Associate, Discovery

Job Location

Cambridge, MA

Description

Carmine Therapeutics is pioneering a powerful new class of gene therapy based on engineered red blood cells extracellular vesicles (RBCEVs). Carmine’s proprietary Gene Therapy platform is well-positioned to address the unmet needs in the delivery of next-generation therapeutic modalities to millions of patients. Founded by Esco Ventures and Professors Harvey Lodish, Minh Le and Jiahai Shi, Carmine’s proprietary Red Cell EV Gene Therapy (REGENT™) platform has the potential to overcome the most critical shortcomings of viral-based gene therapy vectors. The company’s non-immunogenic system has already demonstrated the ability to deliver payloads over 30 kb, and to boost transgene expression through re-dosing.


Carmine was awarded the 2019 Bristol-Myers Squibb’s Golden Ticket to LabCentral (Cambridge, MA) and has established an extensive research collaboration with Takeda Pharmaceuticals. Carmine was also recognized as one of Fierce Biotech’s Fierce15 biotech companies of 2020. Our company is well-situated in developing next-generation non-viral gene therapies to overcome the limitations of AAV-based gene therapy. Carmine is well-capitalized and headquartered in Cambridge, MA, with a location in Singapore.


Carmine’s Discovery team in Cambridge is looking for a Research Associate or Senior Research Associate to join our exciting journey to develop the next generation of gene therapy. This individual will have broad responsibilities to deliver discovery projects and support research needs within the organization. An ideal candidate is independent, meticulous, technically competent, and able to work efficiently across multiple projects.

Responsibilities

  • Carry out and analyze in vivo and in vitro experimental studies to advance RBCEV gene therapy platform and pipelines.

  • Evaluate and interpret collected data and prepare oral presentations or written reports.

  • Contribute to experiment design, troubleshooting, and scientific discussions to achieve R&D milestones.

  • Maintain accurate and detailed documentation of experimental data and inventories on electronic lab notebook.

  • Provide backup support for lab management duties, including procurement and equipment maintenance.

  • Contribute to building a culture that embraces scientific excellence and integrity with a sense of urgency and collaboration with key stakeholders.

  • Support the continued creation and expansion of the company’s intellectual property

  • Perform other related duties incidental to the work described herein

Requirements

  • BS/MS in Biology or a related field with relevant industry/academic experience.

  • Basic laboratory techniques that include cell culture, flow cytometry, and molecular biology.

  • Prior in vivo mouse experience (mouse handling, injections, and routine bleeding) is an advantage.

  • Good communication skills and the ability to work in a fast-paced startup environment.

  • Energetic, highly motivated, supportive, collaborative, and the ability to thrive in an entrepreneurial and multidisciplinary environment.

Please email your resume and cover letter to careers@carminetherapeutics.com to apply for this position.