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Research Associate/Senior Research Associate, Molecular Biology

Job Location

Cambridge, MA

Description

Carmine Therapeutics is pioneering a powerful new class of gene therapy based on engineered red blood cells extracellular vesicles (RBCEVs). Carmine’s proprietary Gene Therapy platform is well-positioned to address the unmet needs in the delivery of next-generation therapeutic modalities to millions of patients. Carmine was awarded the 2019 Bristol-Myers Squibb’s Golden Ticket to LabCentral (Cambridge, MA) and has established an extensive research collaboration with Takeda Pharmaceuticals. Carmine was also recognized as one of Fierce Biotech’s Fierce15 biotech companies of 2020. Our company is well-situated in developing next-generation non-viral gene therapies to overcome the limitations of AAV-based gene therapy. Carmine is based in Cambridge, MA, and Singapore.


We are looking for candidates who enjoy working in a team and can leverage the growth opportunities that an early startup provides. This is an exceptional opportunity for someone excited about cell therapy development and pioneering scientific efforts. We seek a highly motivated, creative, and detail-oriented individual to play a vital role in the scale-up of our genetic improvement platform, engaging in discovery and product development projects. The Research Associate / Senior Research Associate, Molecular Biology, will support various aspects of our molecular biology platform, including vector design, production, and gene expression assays in-vitro and in-vivo. The ideal candidate will be technically talented at designing, producing, and testing novel expression vectors utilizing the latest molecular biology, and gene expression approach.

Responsibilities

  • This is a bench-focused position Responsible for the design, execution, and interpretation of experiments to develop novel non-viral vectors for our RBCEV-based gene delivery platform.

  • Document experimental data in ELN on time

  • Present data to the Molecular Biology team as well as the broader program teams.

  • Develop new scientific and technical skills to support vector development

  • Develop project management skills to support multiple projects with constantly changing priorities

Requirements

  • B.S. or M.S. degree in biology, biochemistry, molecular biology, bioengineering, or a related field

  • 1 to 3 years of hands-on experience with gene expression vector design and construction

  • Participate in molecular and cellular biology experiments, including but not limited to DNA/RNA purification and isolation, DNA and protein gel electrophoresis, DNA/RNA enzymatic treatment and manipulation, PCR/QRT-PCR, mammalian cell (tissue) culture, cell transfection, and transduction methods

  • Familiarity with modern techniques used for DNA synthesis, vector assembly, and cell line-based-reporter assays

  • Hands-on experience with software used to analyze DNA sequencing data

  • Strong organizational skills and ability to interpret data to generate conclusions

  • A collaborative attitude with a desire to learn while delivering high-quality results

Please email your resume and cover letter to careers@carminetherapeutics.com to apply for this position.

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