Scientist/Senior Scientist, In Vivo Sciences

Job Location

Cambridge, MA

Description

Carmine Therapeutics is pioneering a powerful new class of gene therapy based on engineered red blood cells extracellular vesicles (RBCEVs). Carmine’s proprietary Gene Therapy platform is well-positioned to address the unmet needs in the delivery of next-generation therapeutic modalities to millions of patients. Founded by Esco Ventures and Professors Harvey Lodish, Minh Le and Jiahai Shi, Carmine’s proprietary Red Cell EV Gene Therapy (REGENT™) platform has the potential to overcome the most critical shortcomings of viral-based gene therapy vectors. The company’s non-immunogenic system has already demonstrated the ability to deliver payloads over 30 kb, and to boost transgene expression through re-dosing.


Carmine was awarded the 2019 Bristol-Myers Squibb’s Golden Ticket to LabCentral (Cambridge, MA) and has established an extensive research collaboration with Takeda Pharmaceuticals. Carmine was also recognized as one of Fierce Biotech’s Fierce15 biotech companies of 2020. Our company is well-situated in developing next-generation non-viral gene therapies to overcome the limitations of AAV-based gene therapy. Carmine is well-capitalized and headquartered in Cambridge, MA, with a location in Singapore.


Carmine’s Discovery team in Cambridge is looking for a Scientist or Senior Scientist to join our exciting journey to develop the next generation of gene therapy. This individual will have broad responsibilities to lead discovery projects and support research needs within the organization. This individual will be a key driver of our preclinical in vivo studies and external collaborations.

Responsibilities

  • Lead in vivo studies to evaluate the expression of therapeutic proteins, PK/PD, and immune responses of gene therapy prototypes and preclinical drug candidates.

  • Contribute to the design, execution, and analysis of in vivo and in vitro experiments.

  • Mentor and lead research associates to accomplish research goals.

  • Develop and manage relationships with external collaborators and Contract Research Organizations.

  • Present research findings at group meetings, company-wide presentations, and external meetings.

  • Manage IACUC protocols, oversee the update and maintenance of accurate, comprehensive electronic laboratory notebooks.

  • Contribute to building a culture that embraces scientific excellence and integrity with a sense of urgency and collaboration with key stakeholders.

  • Support the continued creation and expansion of the company’s intellectual property

  • Perform other related duties incidental to the work described herein

Requirements

  • Ph.D. in Biology, or a related field with relevant industry or academic experience and a strong publication record.

  • Exceptional candidates with BS/MS and 4+ years of relevant experience may also be considered.

  • Demonstrated hands-on competencies in designing and executing in vivo experiments are required.

  • Proficiency with animal handling and various routes of administration (IV, IP, SC) and blood collection is strongly preferred.

  • Knowledge of gene therapy/nucleic acid delivery/extracellular vesicles is an advantage.

  • Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.

  • Develop effective and efficient working relationships with both internal and external partners.

  • Team-oriented, highly motivated, execution-focused with a strong work ethic, the ability to thrive in an entrepreneurial and multidisciplinary environment.

Please email your resume and cover letter to careers@carminetherapeutics.com to apply for this position.