Scientist/Senior Scientist, Platform Innovation

Job Location

Cambridge, MA

Description

Carmine Therapeutics is pioneering a powerful new class of gene therapy based on engineered red blood cells extracellular vesicles (RBCEVs). Carmine’s proprietary Gene Therapy platform is well-positioned to address the unmet needs in the delivery of next-generation therapeutic modalities to millions of patients. Founded by Esco Ventures and Professors Harvey Lodish, Minh Le and Jiahai Shi, Carmine’s proprietary Red Cell EV Gene Therapy (REGENT™) platform has the potential to overcome the most critical shortcomings of viral-based gene therapy vectors. The company’s non-immunogenic system has already demonstrated the ability to deliver payloads over 30 kb, and to boost transgene expression through re-dosing.


Carmine was awarded the 2019 Bristol-Myers Squibb’s Golden Ticket to LabCentral (Cambridge, MA) and has established an extensive research collaboration with Takeda Pharmaceuticals. Carmine was also recognized as one of Fierce Biotech’s Fierce15 biotech companies of 2020. Our company is well-situated in developing next-generation non-viral gene therapies to overcome the limitations of AAV-based gene therapy. Carmine is well-capitalized and headquartered in Cambridge, MA, with a location in Singapore.


Carmine’s Discovery team in Cambridge is looking for an innovative and motivated Scientist or Senior Scientist to join our exciting journey to develop the next generation of gene therapy. This individual will have broad responsibilities to lead platform innovation projects and contribute to cross-function research and development activities. This individual will drive key optimization efforts to advance our novel gene therapy system and develop targeted delivery to affected tissues in patients.

Responsibilities

  • Develop next-generation processes to produce RBCEV gene therapy through designing and executing innovative and systemic optimizations.

  • Conceptualize, design, and execute studies to evaluate novel gene therapy candidates for multiple disease indications.

  • Design, optimize, and carry out a broad range of assays including cell-based assays, flow cytometry, fluorescent imaging, ELISA, and other molecular or immunoassays.

  • Analyze, interpret, and document data using appropriate programs (e.g., FlowJo and Prism) and present findings at group and company meetings.

  • Manage and train research associates to execute experiments and analyze data.

  • Contribute to building a culture that embraces scientific excellence and integrity with a sense of urgency and collaboration with key stakeholders.

  • Support the continued creation and expansion of the company’s intellectual property.

  • Perform other related duties incidental to the work described herein.

Requirements

  • Ph.D. in cell biology, pharmacology, molecular biology, or related field with relevant industry or academic experience and a strong track record of publication.

  • Exceptional candidates with BS/MS and 4+ years of relevant experience may also be considered.

  • First-hand experience and a deep understanding of molecular and cell biology methods covering a broad range of research techniques are required.

  • Knowledge of gene therapy/nucleic acid delivery/process development/extracellular vesicles is a strong plus.

  • Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.

  • Develop effective and efficient working relationships with both internal and external partners.

  • Team-oriented, highly motivated, execution-focused with a strong work ethic, the ability to thrive in an entrepreneurial and multidisciplinary environment.

Please email your resume and cover letter to careers@carminetherapeutics.com to apply for this position.