Senior Director, Program and Alliance Management

Job Location

Cambridge, MA, USA

Description

Carmine Therapeutics is an EVX company pioneering a powerful new class of drugs based on engineered red blood cells extracellular vesicles (RBCEVs), founded by EVX Ventures and Professors Harvey Lodish, Minh Le and Jiahai Shi. Carmine’s proprietary Red Cell EV Gene Therapy (REGENT™) platform is positioned to address some of the technological unmet needs related to the delivery of next generation therapeutic modalities such as nucleic acids. Carmine was awarded the 2019 Bristol-Myers Squibb’s Golden Ticket to LabCentral (Cambridge, MA) and has established a research collaboration with Takeda Pharmaceuticals in a deal worth over $900M USD. The company is well-capitalized to develop next generation non-viral gene therapies that would overcome most of the limitations of AAV-based gene therapy. Carmine is based both in Cambridge, MA as well as Singapore.


Carmine’s Cambridge location is looking for an engaged and innovative Senior Director to create and lead the Program and Alliance Management function at Carmine. You will work with our leadership team to prioritize and move promising research discoveries into development candidates, and will then work with the CMC, Research, and Clinical Development teams to advance these candidates into clinical trials. Reporting to the Chief Scientific Officer, this position will facilitate long-range planning and prioritization discussions, as well as additional corporate activities.


Responsibilities

  • Responsible for overall portfolio management for both internal and partnered programs.

  • Establish the program management function, including processes and systems.Ensure efficiency and effectiveness by implementing appropriate program management tools.

  • Facilitate the creation of sub-team activities such as regulatory strategy and clinical development plans through cross-functional discussions and achieve product goals within stated time frames and resources by driving decision making.

  • Partner with Research, CMC, and Clinical leads to develop product strategies.

  • Work with the functional team representatives to identify potential issues and ensure contingency planning, problem-solving, and communications as appropriate.

  • As part of the planning process, ensure accurate forecasting, tracking, and budget alignment with Program/Product Team goals.

  • Drive program/asset communication strategy and ensure that communications are managed consistently.

  • Hire and mentor additional Program Managers as dictated by pipeline requirements.  Support Program managers in building team effectiveness, planning, and navigating issues.

  • Support the continued creation and expansion of company’s intellectual property.

  • Perform other related duties incidental to the work described herein.

Requirements

  • A minimum of a B.S. in biological sciences or a related scientific field with an advanced degree preferred, and over 10 years of relevant industry experience.

  • Demonstrated track record of project management success with multi-disciplinary teams from lead identification to clinical proof-of-concept, including internal cross-functional partnering experience.

  • Significant drug development experience and the proven ability to make difficult decisions in a timely fashion based on a high-level perspective.

  • A strategic thinker experienced in bridging the gap between strategy and execution.

  • A mature understanding of dynamics at both the team and organizational level with significant cross-functional leadership capabilities.

  • Exceptional project/program management skills, including timeline and budget development and oversight.

  • Excellent oral, written, and presentation communication skills, with proven efficacy at summarizing and presenting decision points and key considerations.  Regular updates to the leadership team will be required.

  • Ability to proactively identify and address resource limitations in collaboration with functional subject matter experts, and authoritatively manage conflicting priorities.

  • Able to critically evaluate business, scientific, and commercial information.

  • Comfortable with the rapid changes inherent in a startup environment. Experience navigating both success and failure of programs with gravitas.

  • Knowledge of gene therapy/nucleic acid delivery/extracellular vesicles is an advantage.

  • Team-oriented, motivated, highly-organized, detail-oriented, diplomatic, and calm under pressure, with the ability to thrive in an entrepreneurial and multidisciplinary environment.

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