Senior Principal Scientist, Analytical Development (CMC)
Job Location
Cambridge, MA, USA
Description
Carmine Therapeutics is an EVX company pioneering a powerful new class of drugs based on engineered red blood cells extracellular vesicles (RBCEVs), founded by EVX Ventures and Professors Harvey Lodish, Minh Le and Jiahai Shi. Carmine’s proprietary Red Cell EV Gene Therapy (REGENT™) platform is positioned to address some of the technological unmet needs related to the delivery of next generation therapeutic modalities such as nucleic acids. Carmine was awarded the 2019 Bristol-Myers Squibb’s Golden Ticket to LabCentral (Cambridge, MA) and has established a research collaboration with Takeda Pharmaceuticals in a deal worth over $900M USD. The company is well-capitalized to develop next generation non-viral gene therapies that would overcome most of the limitations of AAV-based gene therapy. Carmine is based both in Cambridge, MA as well as Singapore.
The CMC Team in Cambridge is looking for a Senior Principal Scientist to develop and implement an analytical strategy for RBCEVs. Reporting to the VP of CMC, this position will nucleate an analytical development team at Carmine and will create phase-appropriate analytical methods for RBCEV development candidates.
Responsibilities
Design and execute experimental plans in coordination with development objectives of the CMC team
Assist in the recruitment, oversight, and mentoring of a team of scientists and research associates to develop an analytical team within CMC
Stay abreast of the latest scientific and competitive developments for EV purification and apply this knowledge to both team strategy and incoming development candidates
Regularly communicate results to project teams and senior leadership; prepare presentations, reports, patent filings and external communications as required
Contribute to building a culture that embraces scientific excellence and integrity with a sense of urgency and collaboration with key stakeholders
Maintain and manage external CMO relationships with commercial partners
Support the continued creation and expansion of company’s intellectual property
Perform other related duties incidental to the work described herein
Requirements
An experienced analytical scientist with a Ph.D. or M.S. degree in chemistry, biology, engineering or a related scientific discipline
Minimum 5 years (Ph.D.) or 10 years (M.S.) of analytical experience in an industry setting, with novel modality experience preferred
Cross-functional analytical experience required (particle counting, chromatography, and immunoassays)
Demonstrated record of success with strong publication record or patent filings
Experience in leading cross-functional teams in a CMC setting
Knowledge of gene therapy/nucleic acid delivery/extracellular vesicles is an advantage
Team oriented, highly motivated, execution focused with strong work ethic, ability to thrive in an entrepreneurial and multidisciplinary environment