Senior Research Associate, Downstream Purification Development (CMC)

Job Location

Cambridge, MA


Carmine Therapeutics is pioneering a powerful new class of drugs based on engineered red blood cells extracellular vesicles (RBCEVs). Founded by Esco Ventures and Professors Harvey Lodish, Minh Le and Jiahai Shi, Carmine’s proprietary Red Cell EV Gene Therapy (REGENT™) platform has the potential to overcome the most critical short-comings of viral-based gene therapy vectors. The company’s non-immunogenic system has already demonstrated the ability to deliver payloads over 30 kb, and to boost transgene expression through re-dosing . Carmine was awarded the 2019 Bristol-Myers Squibb’s Golden Ticket to LabCentral (Cambridge, MA) and has established a research collaboration with Takeda Pharmaceuticals in a deal worth over $900M USD. The company is well capitalized and headquartered in Cambridge, MA, with an additional location in Singapore.

The CMC Team in Cambridge is looking for a Senior Research Associate to work under the direction of the DSP team to develop and implement purification schemes for RBCEVs. Reporting to the Principal Scientist of Downstream Purification, this position will assist in creating phase-appropriate purification processes for RBCEV development candidates.


  • Execute experimental plans in coordination with development objectives of the CMC team, which are initially to develop scalable purification processes for loaded and unloaded RBCEVs

  • Stay abreast of the latest scientific and competitive developments for EV purification and apply this knowledge to both team strategy and incoming development candidates

  • Assist in presentations, reports, patent filings and external communications as required

  • Contribute to building a culture that embraces scientific excellence and integrity with a sense of urgency and collaboration with key stakeholders

  • Assist in maintaining and managing external CMO relationships with commercial partners

  • Support the continued creation and expansion of company’s intellectual property

  • Perform other related duties incidental to the work described herein


  • A purification scientist with a B.S. or M.S. in bioengineering or a related scientific discipline and 2-5 years of experience in purification in an industry setting, with novel modality experience preferred

  • Experience in the following would be an asset: AKTA purification of multiple biological modalities, UF/DF or TFF experience with larger biological modalities (e.g. viruses), and tech transfer of developed processes to a manufacturing setting

  • Knowledge of gene therapy/nucleic acid delivery/extracellular vesicles is an advantage

  • Team oriented, highly motivated, execution focused with strong work ethic, ability to thrive in an entrepreneurial and multidisciplinary environment

Interested candidates, please submit a CV to