Senior Scientist/Principal Scientist, Downstream Purification Development (CMC)
Carmine Therapeutics is pioneering a powerful new class of drugs based on engineered red blood cells extracellular vesicles (RBCEVs). Founded by Esco Ventures and Professors Harvey Lodish, Minh Le and Jiahai Shi, Carmine’s proprietary Red Cell EV Gene Therapy (REGENT™) platform has the potential to overcome the most critical shortcomings of viral-based gene therapy vectors. The company’s non-immunogenic system has already demonstrated the ability to deliver payloads over 30 kb, and to boost transgene expression through re-dosing. Carmine was awarded the 2019 Bristol-Myers Squibb’s Golden Ticket to LabCentral (Cambridge, MA) and has established a research collaboration with Takeda Pharmaceuticals in a deal worth over $900M USD. The company is well-capitalized and headquartered in Cambridge, MA, with an additional location in Singapore.
The CMC Team in Cambridge is looking for a Senior Scientist or Principal Scientist to develop and implement purification schemes for RBCEVs. Reporting to the VP of CMC, this position will nucleate a downstream purification development team at Carmine and will create phase-appropriate purification processes for the RBCEV platform process and multiple development candidates.
Design improved purification processes for loaded and unloaded RBCEVs, and execute experimental plans in coordination with development objectives of the CMC team
Build a team of junior scientists to achieve DSPD goals
Stay abreast of the latest scientific and competitive developments for EV purification and apply this knowledge to both team strategy and incoming development candidates
Regularly communicate results to project teams and senior leadership; prepare presentations, reports, patent filings, and external communications as required
Contribute to building a culture that embraces scientific excellence and integrity with a sense of urgency and collaboration with key stakeholders
Be the primary point of contact for CMO relationships with pre-clinical and clinical partners
Support the continued creation and expansion of the company’s intellectual property
Perform other related duties incidental to the work described herein
A purification scientist with a Ph.D. in bioengineering or a related scientific discipline and 2-5 years of relevant industry experience, or an MS degree with 7-10 years of relevant industry experience
Novel modality experience preferred
Extensive experience with a wide variety of chromatography and filtration unit operations
Demonstrated record of success with strong publication record or patent filings
Experience with cross-functional teams as a CMC subject matter expert
Knowledge of gene therapy/nucleic acid delivery/extracellular vesicles is an advantage
Team oriented, highly motivated, execution-focused with strong work ethic, ability to thrive in an entrepreneurial and multidisciplinary environment
Please email your resume and cover letter to firstname.lastname@example.org to apply for this position.